Ethylmorphine HCl
A synthetic toxic alkaloid that is an ethyl ether of morphine and is
used especially in the form of its
hydrochloride C19H23NO3·HCl similarly to morphine and codeine
Ethyl-morphine hydrochloride, or dionine, is soluble in water and
alcohol. In dose of 1/2 to 1 grain (0.003-0.06 gm.) it is not so
sedative as its composition would seem to indicate, but it is employed
more or less for cough and mild pain. It is analgesic in the eye, and
has been extensively employed by the ophthalmologists in treatment of
deep-seated ocular pain. Lloyd-Owen finds that a 2 to 5 per cent.
solution dropped in the eye has scarcely any effect on the cornea and
conjunctiva, but is decidedly analgesic in the presence of the
deep-seated pains of iritis, glaucoma, etc. It does not contract the
pupil. Several oculists have reported to me a primary irritation with
chemosis lasting an hour or two. It is probable that its action is not
local, and that it is absorbed through the eye to act on centers.
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